HETERODIMERIC FC REGIONS BINDING MOLECULES

The present invention features inter alia polypeptides comprising heterodimeric Fc regions In addition the instant invention provides methods for treating or preventing a disease or disorder in subject by administering the polypeptides of the invention to said subject

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N

Occupational exposure to N-(cyclohexylthio)phthalimide may occur through inhalation and dermal contact with this compound at workplaces where N-(cyclohexylthio)phthalimide is produced or used(SRC) Exposure of the general population to N-(cyclohexylthio)phthalimide is not expected since during the rubber vulcanization process N-(cyclohexylthio)phthalimide reacts and becomes polymer

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US Patent for Antithrombotic diamines Patent (Patent

This application relates to the use as thrombin inhibitors coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein It also provides novel compounds of formula I processes and intermediates for their preparation and pharmaceutical formulations comprising the novel compounds of formula I

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cyclohexyl n

Synonyms: Cyclohexyl N-Phthalimidyl Sulfide 4 FIRST-AID MEASURES Inhalation: May cause coughing difficult breathing and nausea Call a poison center or doctor if you feel unwell Effects of exposure (inhalation) to substance may be delayed Inhalation of vapors or contact with substance will result in contamination and potential harmful effects

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US Patent Application for Antibodies having altered

The invention provides a method of producing aglycosylated Fc-containing polypeptides such as antibodies having desired effector function The invention also provides aglycosylated antibodies produced according to the method as well as methods of using such antibodies as therapeutics

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US Patent Application for ANTIBODIES HAVING ALTERED

The invention provides a method of producing aglycosylated Fc-containing polypeptides such as antibodies having desired effector function The invention also provides aglycosylated antibodies produced according to the method as well as methods of using such antibodies as therapeutics

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US Patent for Antithrombotic diamines Patent (Patent

This application relates to the use as thrombin inhibitors coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein It also provides novel compounds of formula I processes and intermediates for their preparation and pharmaceutical formulations comprising the novel compounds of formula I

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Single

Patent application title: Single-chain Fc (scFc) regions binding polypeptides comprising same and methods related thereto Inventors: Graham K Farrington (Acton MA US) Graham K Farrington (Acton MA US) Amna Saeed-Kothe (West Roxbury MA US) Ellen Garber (Cambridge MA US) Alexey Alexandrovich Lugovskoy (Woburn MA US) Alexey Alexandrovich Lugovskoy (Woburn MA US)

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US Patent for Antithrombotic diamines Patent (Patent

This application relates to the use as thrombin inhibitors coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein It also provides novel compounds of formula I processes and intermediates for their preparation and pharmaceutical formulations comprising the novel compounds of formula I

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N

Occupational exposure to N-(cyclohexylthio)phthalimide may occur through inhalation and dermal contact with this compound at workplaces where N-(cyclohexylthio)phthalimide is produced or used(SRC) Exposure of the general population to N-(cyclohexylthio)phthalimide is not expected since during the rubber vulcanization process N-(cyclohexylthio)phthalimide reacts and becomes polymer

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N

N-(Cyclohexylthio)phthalimide would be expected to hydrolyze in moist soil and in water a hydrolysis half-life of 23 3 hours at pH 7 and 25 C has been reported for N-(cyclohexylthio)phthalimide(3) N-(Cyclohexylthio)phthalimide is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3 8X10-8 mm Hg

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cyclohexyl n

Synonyms: Cyclohexyl N-Phthalimidyl Sulfide 4 FIRST-AID MEASURES Inhalation: May cause coughing difficult breathing and nausea Call a poison center or doctor if you feel unwell Effects of exposure (inhalation) to substance may be delayed Inhalation of vapors or contact with substance will result in contamination and potential harmful effects

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cyclohexyl n

Synonyms: Cyclohexyl N-Phthalimidyl Sulfide 4 FIRST-AID MEASURES Inhalation: May cause coughing difficult breathing and nausea Call a poison center or doctor if you feel unwell Effects of exposure (inhalation) to substance may be delayed Inhalation of vapors or contact with substance will result in contamination and potential harmful effects

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Carbohydrate Chemistry Volume 33

Carbohydrate Chemistry Volume 33 SPECIALIST PERIODICAL REPORTS Systematicand detailed review coveragein major areas of chemical research A unique servicefor the active researchchemistwith annual or biennial in-depth accounts of progressin particularfields of chemistry in print and online

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Cripto binding molecules

Patent application title: Cripto binding molecules Inventors: Scott Glaser (San Diego CA US) Herman Van Vlijmen (Mechelen BE) Herman Van Vlijmen (Mechelen BE) Alexey Alexandrovich Lugovskoy (Woburn MA US) Alexey Alexandrovich Lugovskoy (Woburn MA US) Michele Sanicola-Nadel (Winchester MA US) IPC8 Class: AA61K39395FI USPC Class: 4241331 Class name: Drug bio

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US Patent Application for ANTIBODIES HAVING ALTERED

The invention provides a method of producing aglycosylated Fc-containing polypeptides such as antibodies having desired effector function The invention also provides aglycosylated antibodies produced according to the method as well as methods of using such antibodies as therapeutics

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