Evodiamine

Evodiamine Molecular Formula C 19 H 17 N 3 O Average mass 303 358 Da Monoisotopic mass 303 137177 Da ChemSpider ID 390624 - 1 of 1 defined stereocentres More details: Systematic name (13bS)-14-Methyl-8 1 3 13b 14-tetrahydroi ndolo[2' 3':3 4]pyri do[2 1-b]quinazolin-5(7H)-one SMILES CN1c2ccccc2C(=O)N3[C H]1c4c(c5ccccc5[nH] 4)CC3

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Evodiamine induces apoptosis and promotes

Evodiamine downregulated HIF-1α and evodiamine plus vorinostat accelerated the degradation of HIF-1α in HCC cells under hypoxia (A) Huh-7 and HepG2 cells were treated with evodiamine at the indicated concentrations for 48 h under hypoxia The expression of HIF-1α was evaluated by western blotting (B) Huh-7 and HepG2 cells were treated with

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Ist Evodiamine Verdnner? Vorteile und Nebenwirkungen

Evodiamine beschleunigt im Krper die Ausscheidung von Theophyllin (welches das aktive Prinzip der bei diesen Erkrankungen verwendeten Arzneimittel ist) wodurch seine Wirksamkeit verringert wird Der beste Weg diese Nebenwirkungen zu vermeiden ist es mit Ihrem Arzt zu sprechen bevor Sie mit der Einnahme von Evodiamin beginnen Und denken Sie daran dass

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Evodiamine

Evodiamine is a quinozole alkaloid isolated from Evodia rutaecarpa described as an agonist of the VR1 (vanilloid receptor subtype 1 TRPV1) with affinity (Ki = 5 95 microM) comparable to that of the prototypical VR1 chemical activator Capsaicin Evodiamine induction of 45 Ca 2+ uptake was competitively antagonized by the Capsaicin antagonist Capsazepine

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A concise synthesis and biological study of evodiamine

Efficient access to evodiamine and its analogues is presented via Lewis acid catalysis In this reaction three chemical bonds and two heterocyclic-fused rings are constructed in one step The reaction shows good functional group tolerance and atom economy and various heteroatom-containing evodiamine analog

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Original Article Evodiamine inhibits proliferation of

Original Article Evodiamine inhibits proliferation of human papillary thyroid cancer cell line K1 by regulating of PI3K/Akt signaling pathway Zhongchuan Lv 1* Dawei Zhao Ruihua Liu 1 Jing Guo2 Yang Lin Min Zhang3 1Department of General Surgery Yantai Yuhuangding Hospital Yantai 264000 China 2Department of General Surgery Qixia City People's Hospital Yantai

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Evodiamine induces apoptosis and promotes

Evodiamine downregulated HIF-1α and evodiamine plus vorinostat accelerated the degradation of HIF-1α in HCC cells under hypoxia (A) Huh-7 and HepG2 cells were treated with evodiamine at the indicated concentrations for 48 h under hypoxia The expression of HIF-1α was evaluated by western blotting (B) Huh-7 and HepG2 cells were treated with

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Evodiamine

Evodiamine is a chemical compound extracted from the plant genus Tetradium which has been shown to reduce fat uptake in mouse studies It is suspected that its mechanism of action is similar to that of capsaicin As such it has been included in some dietary supplements Neither its fat-burning effects in humans nor any potential side effects have been empirically established

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Evodiamine

Evodiamine Molecular Formula C 19 H 17 N 3 O Average mass 303 358 Da Monoisotopic mass 303 137177 Da ChemSpider ID 133343 More details: Systematic name 14-Methyl-8 13 13b 1 4-tetrahydroindolo[2 ' 3':3 4]pyrido[2 1-b]quinazolin-5(7H)-o ne SMILES CN1c2ccccc2C(=O)N3C1 c4c(c5ccccc5[nH]4)CC 3 Copy Std InChi InChI=1S/C19H17N3O/c

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Evodiamine and Its Role in Chronic Diseases

Evodiamine (EVO) is a major alkaloid compound extracted from the dry unripened fruit Evodiae fructus (Evodia rutaecarpa Benth Rutaceae) EVO has a variety of pharmacological activities such as anti-obesity anti-allergenic analgesic anti-tumor anti-ulcerogenic and neuroprotective activities EVO has varying efficacies in animal models and humans Here the

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Ist Evodiamine Verdnner? Vorteile und Nebenwirkungen

Evodiamine beschleunigt im Krper die Ausscheidung von Theophyllin (welches das aktive Prinzip der bei diesen Erkrankungen verwendeten Arzneimittel ist) wodurch seine Wirksamkeit verringert wird Der beste Weg diese Nebenwirkungen zu vermeiden ist es mit Ihrem Arzt zu sprechen bevor Sie mit der Einnahme von Evodiamin beginnen Und denken Sie daran dass

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Antitumor mechanism of evodiamine a constituent from

Antitumor mechanism of evodiamine a constituent from Chinese herb Evodiae fructus in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo Cho-Hwa Liao To whom correspondence should be addressed at: Room 1143 No 1 Jen-Ai Road Sec 1 Pharmacological Institute College of Medicine National Taiwan University Taipei 100 Taiwan

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Evodiamine a plant alkaloid induces calcium/JNK

Furthermore evodiamine-mediated JNK activation was abolished by BAPTA-AM an intracellular calcium scavenger suggesting that evodiamine mediates autophagy via a calcium-JNK signaling pathway Collectively these results suggest that evodiamine induces intracellular calcium/JNK signaling-mediated autophagy and calcium/mitochondria-mediated apoptosis in glioma cells

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Antitumor mechanism of evodiamine a constituent from

Antitumor mechanism of evodiamine a constituent from Chinese herb Evodiae fructus in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo Cho-Hwa Liao To whom correspondence should be addressed at: Room 1143 No 1 Jen-Ai Road Sec 1 Pharmacological Institute College of Medicine National Taiwan University Taipei 100 Taiwan

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Evodia rutaecarpa Supplement — Health Benefits

Evodia rutaecarpa is the plant which bears the berries evodia fructae (Fruits of Evodia) which are eaten in Traditional Chinese Medicine as a warming technique The plant is also touted to reduce pain and gastrointestinal distress and be anti-cancer It has been investigated as a fat burner but no significantly promising evidence has been shown at this moment in time

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Evodiamine induces apoptosis and promotes

Evodiamine downregulated HIF-1α and evodiamine plus vorinostat accelerated the degradation of HIF-1α in HCC cells under hypoxia (A) Huh-7 and HepG2 cells were treated with evodiamine at the indicated concentrations for 48 h under hypoxia The expression of HIF-1α was evaluated by western blotting (B) Huh-7 and HepG2 cells were treated with

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Evodiamine inhibits migration and invasion by Sirt1

Evodiamine (EVO) inhibits cell viability migration and invasion in colorectal cancer cells (a) Chemical structure of Evodiamine (b) HT-29 cells and HCT-116 cells were treated with different concentrations (0 0 375 0 75 1 5 3 6 and 12 μmol/l) of Evodiamine for 24 48 and 72 h and cell viability was detected using the CCK-8 assay (c) Wound-healing assay After treatment

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Evodia Supplement: Benefits Uses Side Effects Dosage

Evodiamine abolishes constitutive inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation thereby suppressing NF-kappaB-regulated antiapoptotic metastatic gene expression up-regulating apoptosis inhibit invasion Biol Chem 2005 280:17203-12 View abstract Tominaga K Higuchi K Hamasaki N et al In vivo action of novel alkyl methyl

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Evodiamine

Evodiamine is a quinozole alkaloid isolated from Evodia rutaecarpa described as an agonist of the VR1 (vanilloid receptor subtype 1 TRPV1) with affinity (Ki = 5 95 microM) comparable to that of the prototypical VR1 chemical activator Capsaicin (sc-3577 Ki = 1 8 microM) Evodiamine induction of 45 Ca 2+ uptake was competitively antagonized by the Capsaicin antagonist

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Evodiamine a plant alkaloid induces calcium/JNK

Furthermore evodiamine-mediated JNK activation was abolished by BAPTA-AM an intracellular calcium scavenger suggesting that evodiamine mediates autophagy via a calcium-JNK signaling pathway Collectively these results suggest that evodiamine induces intracellular calcium/JNK signaling-mediated autophagy and calcium/mitochondria-mediated apoptosis in glioma cells

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Evodiamine

Evodiamine Molecular Formula C 19 H 17 N 3 O Average mass 303 358 Da Monoisotopic mass 303 137177 Da ChemSpider ID 133343 More details: Systematic name 14-Methyl-8 13 13b 1 4-tetrahydroindolo[2 ' 3':3 4]pyrido[2 1-b]quinazolin-5(7H)-o ne SMILES CN1c2ccccc2C(=O)N3C1 c4c(c5ccccc5[nH]4)CC 3 Copy Std InChi InChI=1S/C19H17N3O/c

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